Cd38 Mouse Anti-Human, Buv395, Clone: Hb7, Bd, Mouse Monoclonal Antibody, Each

Details:

The hb7 monoclonal antibody specifically binds to human cd38. Cd38 is a type ii transmembrane glycoprotein of 45 kda with a protein core of 35 kda. The cd38 antigen is expressed on essentially all pre-b lymphocytes, plasma cells, and thymocytes. It is also present on activated t lymphocytes, natural killer (nk) lymphocytes, myeloblasts, and erythroblasts. The antigen is expressed during the early stages of t- and b-lymphocyte differentiation, is lost during the intermediate stages of maturation, and then reappears during the final stages of maturation. The cd38 antigen is expressed on 90% of cd34+ cells, and is not expressed on pluripotent stem cells. Coexpression of cd38 antigen on cd34+ cells indicates lineage commitment of those cells. Cd38 is a counter-receptor of cd31. It is also expressed in t- and b-acute lymphoblastic leukemia (all), burkitt's lymphoma, multiple myeloma, acute myeloid leukemia (aml), and chronic lymphocytic leukemia (cll). The antibody was conjugated to bd horizon™ buv395 which has been exclusively developed by bd biosciences as an optimal dye for use on a 355nm laser equipped instrument. With an ex max at 348nm and an em max at 395nm, this dye has virtually no spillover into any other detector. Bd horizon™ buv395 can be excited with a 355nm laser and detected with a 379/28 filter.