Cd4 Mouse Anti-Human, Apc, Clone: Rpa-T4, Bd, Mouse Monoclonal Antibody, Each

Details:

The rpa-t4 monoclonal antibody specifically binds to cd4, a 59 kda single-chain transmembrane glycoprotein that is expressed on t-helper/inducer cell populations. Cd4 is also expressed on thymocytes subsets and at lower levels on monocytes and macrophages. Cd4 functions as a co-receptor in mhc class ii-restricted antigen-induced t cell activation and as a receptor for human immunodeficiency viruses (hiv). This antibody binds to the d1 domain (cdr1 and cdr3 epitopes) of the cd4 antigen and reacts with approximately 80% of thymocytes and 45% of peripheral blood lymphocytes. Rpa-t4 is capable of blocking hiv-1, gp120, and inhibits syncytium formation.