Cd4 Mouse Anti-Human, Brilliant Violet 605, Clone: Rpa-T4, Bd, Mouse Monoclonal Antibody, Each

Details:

The rpa-t4 monoclonal antibody specifically binds to cd4, a 59 kda single-chain transmembrane glycoprotein that is expressed on t-helper/inducer cell populations. Cd4 is also expressed on thymocytes subsets and at lower levels on monocytes and macrophages. Cd4 functions as a co-receptor in mhc class ii-restricted antigen-induced t cell activation and as a receptor for human immunodeficiency viruses (hiv). This antibody binds to the d1 domain (cdr1 and cdr3 epitopes) of the cd4 antigen and reacts with approximately 80% of thymocytes and 45% of peripheral blood lymphocytes. Rpa-t4 is capable of blocking hiv-1, gp120, and inhibits syncytium formation. This antibody is conjugated to bd horizon bv605 which is part of the bd horizon brilliant™ violet family of dyes. With an ex max of 407-nm and em max of 602-nm, bd horizon bv605 can be excited by a violet laser and detected with a standard 610/20-nm filter set. Bd horizon bv605 is a tandem fluorochrome of bd horizon bv421 and an acceptor dye with an em max at 605-nm. Due to the excitation of the acceptor dye by the green (532 nm) and yellow-green (561 nm) lasers, there will be significant spillover into the pe and bd horizon pe-cf594 detectors off the green or yellow-green lasers. Bd horizon bv605 conjugates are very bright, often exhibiting brightness equivalent to pe conjugates and can be used as a third color off of the violet laser.