Cd4 Mouse Anti-Human, Brilliant Violet 711, Clone: Sk3, Bd, Mouse Monoclonal Antibody, Each

Details:

The sk3 monoclonal antibody specifically binds to cd4. The cd4 antigen is a 55 kda type 1 transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed on t-helper/inducer lymphocytes and monocytes. Cd3+cd4+ t cells comprise approximately 28% to 58% of normal peripheral blood lymphocytes. Cd4 is also expressed on 80% to 95% of normal thymocytes. The cd4 antigen is present in low density on the cell surface of monocytes and in the cytoplasm of monocytes and macrophages (cd3-cd4+). Cd4 serves as a t cell coreceptor for mhc class ii antigen recognition and as a receptor for the human immunodeficiency virus (hiv). The sk3 antibody inhibits hiv binding to cd4+ cells. The antibody was conjugated to bd horizon™ bv711 which is part of the bd horizon™ brilliant violet™ family of dyes. This dye is a tandem fluorochrome of bd horizon™ bv421 with an ex max of 405-nm and an acceptor dye with an em max at 711-nm. Bd horizon™ bv711 can be excited by the violet laser and detected in a filter used to detect cy™5.5 / Alexa fluor™ 700-like dyes (eg, 712/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the alexa fluor™ 700 and percp-cy™5.5 Detectors. However, the spillover can be corrected through compensation as with any other dye combination.