Cd4 Mouse Anti-Human, Buv395, Clone: Sk3, Bd, Mouse Monoclonal Antibody, Each

Details:

The sk3 monoclonal antibody specifically binds to cd4. The cd4 antigen is a 55 kda type 1 transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed on t-helper/inducer lymphocytes and monocytes. Cd3+cd4+ t cells comprise approximately 28% to 58% of normal peripheral blood lymphocytes. Cd4 is also expressed on 80% to 95% of normal thymocytes. The cd4 antigen is present in low density on the cell surface of monocytes and in the cytoplasm of monocytes and macrophages (cd3-cd4+). Cd4 serves as a t cell coreceptor for mhc class ii antigen recognition and as a receptor for the human immunodeficiency virus (hiv). The sk3 antibody inhibits hiv binding to cd4+ cells. The antibody was conjugated to bd horizon™ buv395 which has been exclusively developed by bd biosciences as an optimal dye for use on a 355nm laser equipped instrument. With an ex max at 348nm and an em max at 395nm, this dye has virtually no spillover into any other detector. Bd horizon™ buv395 can be excited with a 355nm laser and detected with a 379/28 filter.