Cd4 Mouse Anti-Human, Pe-Cf594, Clone: Rpa-T4, Bd, Mouse Monoclonal Antibody, Each

Details:

The rpa-t4 monoclonal antibody specifically binds to cd4, a 59 kda single-chain transmembrane glycoprotein that is expressed on t-helper/inducer cell populations. Cd4 is also expressed on thymocytes subsets and at lower levels on monocytes and macrophages. Cd4 functions as a co-receptor in mhc class ii-restricted antigen-induced t cell activation and as a receptor for human immunodeficiency viruses (hiv). This antibody binds to the d1 domain (cdr1 and cdr3 epitopes) of the cd4 antigen and reacts with approximately 80% of thymocytes and 45% of peripheral blood lymphocytes. Rpa-t4 is capable of blocking hiv-1, gp120, and inhibits syncytium formation. This antibody is conjugated to bd horizon™ pe-cf594, which has been developed exclusively by bd biosciences as a better alternative to pe-texas red. Pe-cf594 excites and emits at similar wavelengths to pe-texas red yet exhibits improved brightness and spectral characteristics. Due to pe having maximal absorption peaks at 496nm and 564nm, pe-cf594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as pe-texas red (eg 610/20-nm filter).