Cd40 Hamster Anti-Mouse, Na/Le, Unlabeled, Clone: Hm40-3, Bd, Hamster Monoclonal Antibody, Each

Details:

The hm40-3 antibody reacts with cd40, a 40-50kda glycoprotein expressed on b lymphocytes and other antigen-presenting cells. The cd40 molecule has a central role in b-cell growth and differentiation. Furthermore, interactions of cd40 with its ligand, cd154, are involved in the initiation and effector stages of cell-mediated immune responses. Cd40 may be involved in the triggering of nk cells and nk-t cells. Soluble hm40-3 antibody stimulates splenic and peritoneal b cells to proliferate in vitro. This antibody also induces spleen b cells to express the costimulatory molecules cd80 (b7-1) and cd86 (b7-2). Hm40-3 mab has been demonstrated to inhibit the binding of soluble cd154 (gp39, cd40 ligand) to soluble cd40 and to cell-surface cd40. This hamster mab to a mouse leukocyte antigen has been observed to cross-react with similar populations of lewis, sprague-dawley, and lou16 rat leukocytes.