Cd40 Mouse Anti-Human, Unlabeled, Clone: 41, Bd, Mouse Monoclonal Antibody, Each

Details:

Cd40, a member of the tnf receptor family, contains a cysteine-rich n-terminal domain and a ser/thr-rich region preceding the transmembrane domain. On b cells, signaling through cd40 induces cell growth and differentiation, mediates cell survival within the germinal center, and upregulates the expression of costimulatory and adhesion molecules, such as b7.1, B7.2, And icam-1. The interaction of cd40 on b cells and cd40l on activated cd4+ t cells is essential for immune functions, such as immuoglobulin class switching. Signal transduction through cd40 pathways involves interaction with proteins such as trafs (traf2, traf3, traf5, and traf6); jak 3; and tyr phosphorylation of proteins, such as lyn, syk, pi-3-kinase, stat3, and stat5. In traf2-deficient mice, cd40-mediated b cell proliferation and nfκb activation are defective. Ku70 and ku80 associate with the membrane-proximal region of cd40 in human primary b cells and the engagement of cd40 leads translocation of ku proteins to the nucleus. Thus, cd40 interacts with a variety of signal transducers which mediate its role in b cell survival, growth, differentiation, and immunoglobulin class switching.