Cd41a Mouse Anti-Human, Fitc, Clone: Hip8, Bd, Mouse Monoclonal Antibody, Each

Details:

The hip8 monoclonal antibody specifically binds to the α-chain of cd41. Cd41 is also known as integrin αiib or platelet gpiib. The calcium-dependent complex of cd41 and cd61 (β3 integrin or gpiiia) is normally expressed on platelets and megakaryocytes. The cd41/cd61 complex is the receptor for fibrinogen, fibronectin and von willebrand factor, and mediates platelet adhesion and aggregation. Cd41 (clone hip8) completely inhibits adp-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. This antibody is useful in the morphological and physiological studies of platelets and megakaryocytes.