$ 489.38
Details:
The 104 monoclonal antibody recognizes the cd45 (leukocyte common antigen) present on all leucocytes of most mouse strains (eg, a, akr, balb/c, cba/ca, cba/j, c3h/he, c57bl, c57br, c57l, c58, dba/1, dba/2, nzb, swr, 129). This alloantigen was originally named ly-5.1, And this was the designation at the time that the antibody was characterized. The designation was later changed from ly-5.1 To ly-5.2 To conform with the convention that the .2 Alloantigen designations be assigned to the c57bl/6 strain. Mab 104 has been reported not to react with leucocytes of the mouse strains expressing the cd45.1 Alloantigen (eg, riii, sjl/j, sts/a, and da). Cd45 is a member of the protein tyrosine phosphatase (ptp) family: its intracellular (cooh-terminal) region contains two ptp catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated a, b, and c, respectively), plus differing levels of glycosylation. The cd45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The cd45 isoforms play complex roles in t-cell and b-cell antigen receptor signal transduction. The 104 antibody has been reported to inhibit some responses of b cells, from mice expressing the cd45.2 Alloantigen, to certain antigens and lps. In addition, reduction of serum igg levels and amelioration of autoimmune renal pathology were reported in mab 104-treated systemic lupus erythematosus-prone mice. This antibody is conjugated to bd horizon pe-cf594, which has been developed exclusively by bd biosciences as a better alternative to pe-texas red™. Pe-cf594 excites and emits at similar wavelengths to pe-texas red™ yet exhibits improved brightness and spectral characteristics. Due to pe having maximal absorption peaks at 496nm and 564nm, pe-cf594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as pe-texas red™ (eg, 610/20-nm filter).
