Cd49d Mouse Anti-Human, Unlabeled, Clone: 9f10, Bd, Mouse Monoclonal Antibody, Each

Details:

Reaacts with the integrin α4 chain, which is expressed as a heterodimer with either of two β subunits, β1 (cd29) or β7. The α4β 1 integrin (vla-4) is expressed on lymphocytes, monocytes, thymocytes, nk cells, and several b- and t-cell lines, and mediates binding to vcam-1 (cd106) and the cs-1 region of fibronectin. The α4β7 integrin has a similar tissue distribution, except it is found on only a small subpopulation of thymocytes. Integrin α4β7 also binds fibronectin and vcam-1, and has been shown in the mouse to preferentially bind the mucosal vascular addressin molecule, madcam-1. This antibody is useful for studies of the expression and function of a4 chain-containing integrins. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at bd biosciences pharmingen during antibody development only or reported in the literature.