Cd54 (Icam-1) Mouse Anti-Human, Unlabeled, Clone: 28, Bd, Mouse Monoclonal Antibody, Each

Details:

The migration of t cells through lymph nodes and their interactions with antigen presenting cells (apcs) involve adhesion molecules on the surfaces of the t cell and the cell with which it interacts. These molecules include the selectins, the integrins, members of the immunoglobulin superfamily, and some mucin-like proteins. The integrins mediate adhesion between cells and between cells and the extracellular matrix. Lfa-1 (lymphocyte function-associated antigen 1), a member of the β2 integrin family, is expressed on t cells, neutrophils, and macrophages and is thought to be the most important adhesion molecule for lymphocyte activation. It interacts with members of the immunoglobulin superfamily, the intercellular adhesion molecules: icam-1, -2, and -3. Icam-1 and icam-2 are expressed on endodthelium and apcs, while icam-3 is expressed only on leukocytes. Icam-1 is most homologous to neural cell adhesion molecule and myelin-associated glycoprotein. It is a 55kda glycoprotein that is heavily glycosylated to form 90kda to 115kda proteins. Its interactions with lfa-1 are necessary for ctl and nk mediated killing, t and b cell responses, and immune cell extravasation.Host species: mouseclone: 28isotype: igg1species reactivity [for features main]: humanimmunogen: human cd54/icam-1 aa. 46-160Immunofluorescence, western blotting