Cd70 Mouse Anti-Human, Brilliant Violet 786, Clone: Ki-24, Bd, Mouse Monoclonal Antibody, Each

Details:

The ki-24 monoclonal antibody specifically binds to human cd70. Cd70 is a type ii transmembrane glycoprotein and member of the tnf superfamily. Cd70 is also known as tumor necrosis factor ligand superfamily member 7 (tnfsf7), cd27 ligand (cd27-l, cd27l, cd27lg), and ki-24 antigen. The cd70 antigen immunoprecipitates as five bands (50, 70, 90, 100 and 160 kda) under non-reducing conditions. Cd70 is strongly expressed on reed-sternberg cells, some activated t or b cells and epstein barr virus (ebv)-positive lymphoblastoid cell lines. Cd70 plays roles in the activation, proliferation and differentiation of b cells and t cells including the enhanced production of cytotoxic t cells. The antibody was conjugated to bd horizon bv786 which is part of the bd horizon brilliant™ violet family of dyes. This dye is a tandem fluorochrome of bd horizon bv421 with an ex max of 405-nm and an acceptor dye with an em max at 786-nm. Bd horizon bv786 can be excited by the violet laser and detected in a filter used to detect cy™7-like dyes (eg, 780/60-nm filter).