Cd73 Mouse Anti-Human, Brilliant Violet 421, Clone: Ad2, Bd, Mouse Monoclonal Antibody, Each

Details:

The ad2 monoclonal antibody specifically binds to ecto-5'-nucleotidase, a 70 kda, glycosyl phosphatidylinositol (gpi)-anchored glycoprotein. Cd73 is expressed on subsets of t and b lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during t and b cell development. Cd73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (amp) converting it to adenosine. It has been suggested that cd73 can mediate costimulatory signals in t cell activation and adhesion of lymphocytes to endothelium. The antibody was conjugated to brilliant violet 421 and has been developed in collaboration with sirigen. With an ex max of 407-nm and em max at 421-nm, brilliant violet 421 can be excited by the violet laser and detected in the standard pacific blue filter set (eg, 450/50-nm filter). Brilliant violet 421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to pacific blue conjugates.Host species: mouseclone: ad2isotype: igg1, κspecies reactivity: humanflow cytometry