Cd8 Mouse Anti-Human, Apc-H7, Clone: Sk1, Bd, Mouse Monoclonal Antibody, Each

Details:

Cd8 recognizes the 32kda a-subunit of a disulfide-linked bimolecular complex. The majority of peripheral blood cd8+ t lymphocytes express an a/b heterodimer (mr 32, 30kda), while cd8+cd16+ natural killer (nk) lymphocytes and cd8+ t-cell receptor (tcr)-γ/δ+ lymphocytes express a/a homodimer (mr 30kda). Cd8+tcr-α/β+ lymphocytes can express either an α/α homodimer or α/β heterodimer. The cd8 antigenic determinant binds to class i major histocompatibility (mhc) molecules resulting in increased adhesion between the cd8+ t lymphocytes and target cells. Binding of the cd8 antigen is coupled to a protein tyrosine kinase p56lck. The cd8:p56lck complex can play a role in t-lymphocyte activation through mediation of the interactions between the cd8 antigen and the cd3/tcr complex.Host species: mouseclone: sk1isotype: igg1 κspecies reactivity: humanimmunogen: human peripheral blood t cellsflow cytometry