Cd81 Mouse Anti-Human, Percp-Cy5.5, Clone: Js-81, Bd, Mouse Monoclonal Antibody, Each

Details:

The js-81 monoclonal antibody specifically binds to cd81, which is also known as, target of the antiproliferative antibody 1 (tapa1, tapa-1), or tetraspanin-28 (tspan-28/tspan28). Cd81 is an ∽26 kda transmembrane protein that belongs to the tetraspanin (tm4sf) family. It is involved in cell growth and signal transduction. Cd81 has a very broad cellular distribution, being expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. In hematopoietic cells, the cd81 antigen is expressed on b and t lymphocytes, nk cells, thymocytes, eosinophils, germinal center follicular dendritic cells, and to a variable extent on monocytes. The cd81 antigen is not expressed on neutrophils, platelets, or erythrocytes. Cd81-specific antibodies have been shown to have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. They are also reported to induce homotypic cell aggregation. Immunoprecipitation studies reveal that cd81 is a component of a multimolecular complex of cd19, cd21, and cd225 that is involved in the activation and control of b cell growth.