Cd86 Mouse Anti-Human, Na/Le, Unlabeled, Clone: It2.2, Bd, Mouse Monoclonal Antibody, Each

Details:

It2.2 Recognizes a 75kda cell surface protein, cd86 (b70/b7-2), expressed primarily on monocytes and activated b cells including lymphoid cells in germinal centers and epstein-barr virus transformed b-cell lines. Cd86 is the second ligand for cd28 and ctla-4 and may play an important role in costimulation of t cells in primary immune response. Competitive binding assays demonstrate that, while both it2.2 And fun-1 (anti-cd86) recognize the same molecule, they react with different epitopes. It2.2 Blocks costimulation activity of cd86 in functional studies and blocks binding of human ctla-4-ig fusion protein to b70 gene-transfected cells.