Cdk2 Mouse, Unlabeled, Clone: 55, Bd, Mouse Monoclonal Antibody, Each

Details:

Cyclin-dependent kinase 2 (cdk2) is a member of a family of cdc2-related cell cycle protein kinases. Cdk2 shares 60% identity with cdc2 and its activity is regulated by phosphorylation in a similar fashion. Cdk2 is expressed earlier in the cell cycle than is cdc2. Like p34 [cdc2], p33 [cdk2] associates with cyclin a in human cells. However, kinase activity associated with cyclin a-cdk2 is present in s phase, whereas, the kinase activity associated with cyclin a-cdc2 is found only in g2. Cdk2 can also complex with cyclins e, d1, and d3. It is not known if the d cyclins can form active complexes with cdk2. Cyclin e-cdk2 kinase is active in the g1 and s phases of the cell cycle and is important (as is cyclin a-cdk2) for the progression from g1 to s phase. The levels of cyclin a-cdk2 are maximal at the g1/s transition and both cdk2 and cyclin a associate with dna in the initiation complex during replication. The rb protein has been identified as a substrate for cdk2-cyclin e and/or cdk2-cyclin a in vivo. This observation is supported by further evidence which shows that cdk2 is activated and specifically localized to the nucleus during late g1, s phase, and g2.