Connexin-43 Mouse, Unlabeled, Clone: 2, Bd, Mouse Monoclonal Antibody, Each

Details:

Gap junctions are intercellular protein pores. They enable cell-to-cell communication by allowing passage of ions and other small molecules. The subunits of gap junction channels are assembled from a family of proteins called connexins. Individual connexin molecules join to make hexameric hemichannels termed connexons; these structures dock to connexons on neighboring cells, forming gap junction pores. Connexin-43 is a member of the connexin family possessing four transmembrane regions, with cytoplasmic amino and carboxyl terminals. It undergoes rapid turnover in the cell and its monomers may reside in the er/golgi network, forming a reservoir available for assembly upon degradation of existing connexin-43 channels. In addition, it is believed that phosphorylation of connexin-43 plays a regulatory role both in the assembly of connexons and in gating activity at the gap junction.Host species: mouseclone: 2isotype: igg2species reactivity: ratimmunogen: rat connexin-43 aa. 252-270Formula weight [chemical]: 43kdaimmunofluorescence, immunohistochemistry, immunoprecipitation, western blotting