Crik Mouse, Unlabeled, Clone: 6, Bd, Mouse Monoclonal Antibody, Each

Details:

Citron was identified by its interactions with activated rho and rac. It contains a zinc finger (zf) region, a pleckstrin homology (ph) domain, a citron/mrck/gek (cmg) domain, and a coiled-coil domain with a rho-rac binding region (rrb). Citron binds to psd-95 via its c-terminal tsxv motif and the pdz domain on psd-95. This association occurs at post synaptic densities where citron-psd-95 may provide a specific link between the rho signaling cascade and the synaptic nmda receptor complex. Citron rho-interacting kinase (crik) and crik short kinase (crik-sk) are ser/thr kinase isoforms of the myotonic dystrophy kinase family. Crik contains full-length citron, with an n-terminal kinase domain. Crik-sk is a splice variant that contains only the kinase domain. Crik co-localizes with actin in keratinocytes and co-expression of crik and rho increases crik kinase activity two-fold. In addition, crik mutants cause abnormal contraction during cytokinesis. Crik is expressed highest in testis, but is also present in brain, spleen, lung, and kidney. Thus, crik is a ser/thr kinase that functions downstream of rho during events such as cytokinesis and synaptic transmission.Immunofluorescence, western blotting