Ctcf Mouse, Unlabeled, Clone: 48, Bd, Mouse Monoclonal Antibody, Each

Details:

The family of nucleic acid-binding c2h2 type zinc finger transcription factors is divided into two classes. One class consists of small proteins (gli1, krox-20, wt1, egr-1, and sp1) with conserved zinc finger clusters of 3 to 5 units, while the other class (znf91, znf74, zfp37, ctcf) can contain more than 10 zinc finger clusters. Ctcf is a ubiquitously expressed, highly conserved transcription factor that contains 10 c2h2- and 1 c2h-type zinc-finger motifs. Ctcf binds to and represses transcription at the promoter-proximal regions of c-myc oncogenes, while ctcf can bind to and activate transcription at the promoter for amyloid β. Another mechanism of ctcf-mediated repression may include binding to insulator regions between enhancers and promoters resulting in enhancer blocking. In addition, ctcf gene may be a candidate tumor suppressor gene, since it localizes to a narrow cancer-associated chromosome region, and has been shown to have tumor-specific rearrangements in breast cancer patients. Thus, ctcf transcriptional regulation may be important for cell cycle progression, differentiation, apoptosis, and tumorigenesis.Immunofluorescence, western blotting