Cyclin A Mouse Anti-Human, Unlabeled, Clone: Bf683, Bd, Mouse Monoclonal Antibody, Each

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Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. The main cyclin-cdks complexes formed in vertebrate cells are cyclin d-cdk4 (g0/g1), cyclin e-cdk2 (g1/s), cyclin a-cdk2 (s) and cyclin b1-cdk1 (g2/m). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27kip1. Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.G., C-abl and sv40 large t-ag), tumor suppressor genes (e.G., Retinoblastoma protein, rb), nucleolin and others. Cyclin a is involved in both s-phase and g2/m transitions of the cell cycle through its association with cdk2 and cdk1, respectively. Cyclin a may also form a complex with the adenovirus oncoprotein e1a which has dna binding activity. Human cyclin a has been reported to migrate between 54-60kda by sds-page and clone bf683 reportedly does not cross-react with mouse, rat or mink cyclin a.Host species: mouseclone: bf683isotype: igespecies reactivity: humanimmunogen: human cyclin a recombinant proteinformula weight [chemical]: 54-60kdaflow cytometry, immunoprecipitation, western blotting