Cyclin D3 Mouse, Unlabeled, Clone: 1, Bd, Mouse Monoclonal Antibody, Each

Details:

Several classes of cyclins (a-e) have been described. These proteins act as regulatory subunits for cyclin-dependent kinases (cdks). The synthesis and degradation of cyclins is tightly controlled in a cell cycle specific manner. There are at least 3 different d-type cyclins whose relative levels vary among cell types. Cyclin d3 is known to associate with cdk5 and weakly with cdk2. Cdk4 is preferentially bound by cyclin d1. However, in t cells which do not express cyclin d1, cdk4 associates with cyclins d2 and d3. While bound to cdks, the d-type cyclins also associate with the polymerase-δ subunit, pcna. Cyclin d3 has also been shown to bind prb in vitro. This suggests that prb may be an in vivo substrate of d-type cyclins. This antibody is routinely tested by western blot analysis. Other applications were tested at bd biosciences pharmingen during antibody development only or reported in the literature.