Disabled-2/P96 Mouse, Unlabeled, Clone: 52, Bd, Mouse Monoclonal Antibody, Each

Details:

Csf-1 is a growth factor that stimulates the growth and differentiation of immature lymphocytes and is required for the survival of mononuclear phagocytes. Binding of csf-1 induces dimerization and autophosphorylation of its receptor. This results in the activation of several signal transduction pathways. A unique 96 kda protein is a component in the csf-1 signal transduction cascade. P96 is phosphorylated on serine following mitogenic stimulation of a mouse macrophage cell line. P96 contains three potential c-terminal erk kinase phosphorylation sites, as well as several proline-rich sequences that are potential binding sites for sh3-containing proteins. Structural similarities have been found between p96 and dab, a product of the drosophila disabled gene, and p96 was also identified as disabled-2 (dab-2) and as differentially expressed in ovarian β receptor to the smad family of transcription factors. Thus, dab-2/p96 is an important adaptor molecule in growth factor signaling pathways.