Dynamin Mouse, Unlabeled, Clone: 41, Bd, Mouse Monoclonal Antibody, Each

Details:

Dynamin is a nerve terminal phosphoprotein with intrinsic gtpase activity which plays an important role in endocytosis. This gtpase activity is stimulated in vitro by microtubules, sh3 domain-containing proteins, phospholipids, and protein kinase c (pkc)-mediated phosphorylation. There are at least two distinct dynamin genes in mammals, which show 79% identity, encoding proteins dynamin i and dynamin ii. Dynamin i is expressed almost exclusively in the central nervous system while dynamin ii expression is ubiquitous. Depolarization stimulates synaptic vesicle recycling and dynamin i is subsequently dephosphorylated. This rapid dephosphorylation is mediated by calcineurin which acts as a switch for depolarization-initiated synaptic vesicle endocytosis. The c-terminus of dynamin contains two clusters of proline-rich sh3 domain binding proline motifs which interact with known sh3 domain proteins during tyrosine kinase receptor activation. It is reported that clone 41 detects both dynamin i and dynamin ii.