E-Cadherin Mouse, Alexa Fluor 488, Clone: 36/E-Cadherin, Bd, Mouse Monoclonal Antibody, Each

Details:

E-cadherin is a 120-kda transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, e-cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These e-cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of e-cadherin in these cells reduces invasiveness. Thus, loss of expression or function of e-cadherin appears to be an important step in tumorigenic progression. The 36/e-cadherin monoclonal antibody recognizes the cytoplasmic domain of e-cadherin, regardless of phosphorylation status. The peptide immunogen was generated from human e-cadherin aa. 735-883. Note: investigators are advised that this antibody has some degree of cross-reactivity to p-cadherin.