E2f1 (Phospho S364), Rabbit, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Phosphopeptide Of E2f1, Each

Details:

The protein encoded by this gene is a member of the e2f family of transcription factors. The e2f family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small dna tumor viruses. The e2f proteins contain several evolutionally conserved domains found in most members of the family. These domains include a dna binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (dp), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, e2f2 and e2f3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein prb in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [Provided by refseq