Calbiochem Suramin, Sodium Salt, A Reversible And Competitive Inhibitor Of Protein Tyrosine Phosphatases., Each

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A reversible and competitive inhibitor of protein tyrosine phosphatases. An anti-neoplastic, anti-angiogenic agent that uncouples g-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits gdp-gtp exchange, the rate limiting step in the activation of gα-subunits. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerases i and ii. Inhibits ca2 -atpase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors, including egf, pdgf, and tgf-β. An inhibitor of phospholipase d (ic50 = 15μm). Reported to interact with atp-binding enzymes and p2-purinergic receptors. An effective inhibitor of angiogenesis in the calmodulin assay when given in combination with angiostatic steroids.