Complement C3a Des-Arg, Human, Protein, Each

Details:

Native, human des-arg c3 complement component. Single chain, 76 amino acid peptide. Once the c3a peptide has been produced in human plasma or serum, it is rapidly converted to c3a des-arg upon removal of the c-terminal arginine by endogenous serum carboxypeptidase n. This enzymatic process is considered to be a major mechanism for controlling c3a function in vivo because c3a des-arg has <1% of the biological activity expressed by the c3a peptide. Therefore, c3a des-arg can serve as a negative control molecule in experiments involved with the biological activities of the intact c3a anaphylatoxin peptide.