Fcμ Receptor Mouse Anti-Human, Biotin, Clone: Hm14-1, Bd, Mouse Monoclonal Antibody, Each

Details:

The hm14-1 monoclonal antibody specifically binds to the faim3 -encoded high affinity receptor for igm (also known as, fcµ receptor, fcμr, fc mu receptor, immunoglobulin mu fc receptor, fcmr, igm fc receptor). The fcμr is a type 1 transmembrane glycoprotei n that contains an extracellular ig-like domain with sequence similarities to fcα/μr and pigr. It is likewise known as fas apoptotic inhibitory molecule 3, toso or regulator of fas-induced apoptosis toso based on its capacity to counter apoptosis mediated by fas/cd95 (or tnf) in some experimental model systems. Fcμrs are expressed by b cells, cd4 t cells, cd8 t cells, and nk cells and are highly expressed on chronic lymphocytic leukemia cells. Fcμrs may play roles in cellular activation, antigen presentation and igm-dependent cell-mediated cytotoxicity. The relatively long cytoplasmic tail of fcμr contains several conserved tyrosine and serine residues. These get phosphorylated after fcμr ligation with ig m immune complexes and may initiate signaling responses. Lymphocyte fcμrs can mediate the internalization of igm-bound antigens including microbial and viral antigens. This in turn may cause cellular activation due to subsequent antigen processing and exposure of activating ligands to intracellular receptors including toll-like receptors. The hm7-10 antibody, a related fcμr-specific antibody, reportedly recognizes an epitope near the igm ligand binding site of the fcμr whereas the hm14-1 antibody does not.