Foxp3 Mouse Anti-Human, Alexa Fluor 488, Clone: 259d/C7, Bd, Mouse Monoclonal Antibody, Each

Details:

The 259d/c7 antibody reacts with the human foxp3 transcription factor, a member of the forkhead or winged helix family of transcription factors. The expression of foxp3, also known as scurfin, ipex and jm2, has been found to be associated with cd4+ regulatory t cells and represents a specific marker for these cells. Flow-cytometric analysis has shown that foxp3 is expressed by the majority of cd4+cd25+high t cells in peripheral blood while less than half of cd4+cd25int cell population are foxp3 positive. Approximately 5-10% of peripheral cd4+ cells are cd4+cd25+ t regulatory cells. T regulatory cells are thought to play a critical role in the control of t cell mediated autoimmunity by suppressing the proliferation and cytokine production of other t cells. To support this hypothesis, it has been found that foxp3 is mutated in scurfy (sf) mice. The 259d/c7 antibody reacts with all currently identified isoforms of human foxp3 and is cross-reactive with cynomolgus, rhesus and baboon.