Fzd6, Rabbit, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Peptide Of Fzd6, Each

Details:

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the n-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a c-terminal pdz domain-binding motif. This protein functions as a negative regulator of the canonical wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants. [Provided by refseq