GΑQ Mouse, Unlabeled, Clone: 10, Bd, Mouse Monoclonal Antibody, Each

Details:

The gtp binding regulatory proteins (g proteins) consist of three subunits: α, β, and γ. These heterotrimeric proteins function at membranes to relay signals from cell surface receptors to intracellular effectors. The α subunit is unique for each g protein and contains the site of gtp binding and hydrolysis, as well sites for receptor and effector interactions. The βγ subunit complex interacts directly with receptors and the α subunit. The gα family includes four families: the gαs family including gαs , gαo1f, and gαt, the gαi family including gαi, gαo, and gαz, the gαq/gα11 family and the gα12/13 family. The gαq protein is 88% homologus with gα11 and both are widely expressed. These g proteins activate phospholipase c proteins, which induce calcium signaling events. G protein coupled receptors (gpcrs) involved in regulating wnt signaling activate gαq, phospholipase cβ, and induce calcium-dependent activation of calpain. These events promote β-catenin nuclear export and proteolysis. Gαq has also been implicated in metabotropic glutamate receptor signaling. Thus, gαq isoforms activate phospholipase c proteins in various g-protein coupled receptor pathways.Immunofluorescence, western blotting