Hax-1 Mouse, Unlabeled, Clone: 52, Bd, Mouse Monoclonal Antibody, Each

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Cell-cell interactions in the immune system, mediated by membrane-bound antigen receptors, trigger a cascade of signaling mechanisms collectively known as the t-cell response. Upon antigen binding, cellular tyrosine kinases are activated resulting in the phosphorylation of hs1 or lck-binding protein 1 (lckbp1), which is involved in thymic negative selection. Hs1 is one of the earliest intracellular proteins to be tyrosine phosphorylated in response to antigen-receptor cross-linking in t cells. Hax-1 (hs1-associated protein x-1) is a 35kda protein found associated with hs1 by co-immunoprecipitation assays and the two-hybrid system. Hax-1 is ubiquitously expressed and localized in the mitochondria, endoplasmic reticulum, and the nuclear envelope. The hs1-hax-1 complex may be critical for signal transduction pathways initiated by antigen presentation to t cells.Immunofluorescence, immunoprecipitation, western blotting