Human Bace2 (Aa 503-518), Synthetic Peptide, Synthetic Peptide, Each

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Human bace2 (residues 503-518) synthetic peptide, pep-167, from invitrogen.Bace2 or beta secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (app). Bace2 cleaves app between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble app. Bace2 is also know to cleave app between residues 671 and 672. Accumulation of app is a signature of alzheimer disease and frequent complication of adult down syndrome patients. Pep-167 is a 17 amino acid synthetic peptide whose sequence is derived from human bace2 protein. The sequence of this peptide is (amino to carboxy terminus): c-p (503)-e-v-v-n-d-e-s-s-l-v-r-h-r-w-k (518)this peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human bace2, catalog # pa1-754. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (∽70-fold) for competitive inhibition of antibody-protein binding reactions.Reconstitute with 0.1 Ml of distilled water.