Human Cd25, Recombinant Protein, Recombinant Protein, Each

Details:

Il-2 receptor alpha (human) recombinant protein, rp-75592, from invitrogen.Cd25 (il2 receptor alpha chain/il2ra) is a cytokine that plays a role in the proliferation of t and b lymphocytes. The receptor of this cytokine (il2ra) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (il4) and interleukin 7 (il7). Il2ra, il2r beta chain (il2rb), and the il2r gamma chain (il2rg), constitute the high-affinity il2 receptor. Homodimeric il2ra chains result in low-affinity receptor, while homodimeric il2rb chains produce a medium-affinity receptor. The expression of il2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. Il2 is primarily produced by mature t cells. Il2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. Il-2 stimulates the proliferation of b cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. This product contains purified recombinant human il-2 receptor alpha protein with an n-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.