Human Il-1 Beta, Recombinant Protein, Recombinant Protein, Each

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Il-1 beta (human) recombinant protein, rp-75584, from invitrogen.Interleukin-1 beta (il-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. Il-1 beta is synthesized in response to inflammatory stimuli as a 31 kda inactive pro-form that accumulates in the cytosol. Cleavage of pro-il-1 beta into the active 17 kda protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-il-1 beta. Il-1 beta lacks a signal sequence peptide for classical er/golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although il-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. Il-1 beta signals through two receptors, il-1ri and il-1rii, both of which are shared with il-1 alpha. Il-1 beta activity can be moderated by il-1 receptor antagonist (il-1ra), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Il-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of il-1 beta have been associated with many chronic inflammatory conditions il-1 beta neutralizing antibodies potential therapeutic value. Rp-75584 contains purified recombinant human il-1 beta protein with an n-terminal hexahistidine tag. Rp-75584 may be used as a positive control in many immunological assays. This protein has a molecular weight of ∽21.88 Kda.