Ifn Gamma Mouse Anti-Human, Brilliant Violet 421, Clone: B27, Bd, Mouse Monoclonal Antibody, Each

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The b27 monoclonal antibody specifically binds to human interferon-γ (ifn-γ). Ifn-γ is a potent multifunctional cytokine that is produced by several activated cell types including nk, nkt, cd4+tcrαβ+, cd8+tcrαβ+, and tcrγδ+ t cells. Ifn-γexerts its biological effects through specific binding to the high-affinity ifn-γ receptor complex comprised of ifn-γβ subunits. In addition to its antiviral effects, ifn-γupregulates a number of lymphoid cell functions including the antimicrobial and antitumor responses of macrophages, nk cells, and neutrophils. In addition, ifn-γcan exert strong regulatory influences on the proliferation, differentiation, and effector responses of b cell and t cell subsets. These influences can involve ifn-γ’s capacity to boost mhc class i and ii expression by antigen-presenting cells as well as to direct effects on b cells and t cells themselves. Human ifn-γis a 14-18 kda glycoprotein containing 143 amino acid residues. B27 is a neutralizing antibody. The use of b27 antibody for epitope mapping of human ifn-γ has been described. The b27 antibody has been reported not to bind to denatured ifn-γ.