Il-1 Beta Rabbit Anti-Human, Mouse, Rabbit Recombinant Polyclonal Antibody, Each

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This antibody is predicted to react with mouse, rat, non-human primate and rabbit based on sequence homology. Intact igg appears on a non-reducing gel as ∽150 kda band and upon reduction generating a ∽25 kda light chain band and a ∽50 kda heavy chain. Recombit rabbit polyclonal antibodies are unique offerings from thermo fisher scientific. They are comprised of a selection of multiple different recombit monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombit antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombit rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.Interleukin-1 beta (il-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. Il-1 beta is synthesized in response to inflammatory stimuli as a 31 kda inactive pro-form that accumulates in the cytosol. Cleavage of pro-il-1 beta into the active 17 kda protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-il-1 beta. Il-1 beta lacks a signal sequence peptide for classical er/golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although il-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. Il-1 beta signals through two receptors, il-1ri and il-1rii, both of which are shared with il-1 alpha. Il-1 beta activity can be moderated by il-1 receptor antagonist (il-1ra), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Il-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of il-1 beta have been associated with many chronic inflammatory conditions il-1 beta neutralizing antibodies potential therapeutic value.