Il-13, Monkey, 1mg, Each

Details:

Il-13, interleukin-13, monkey: interleukin-13 (il-13) is expressed by the il13 gene and secreted by many cell types, especially t helper type 2 (th2) cells.The high solution from of il-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration. Targeted deletion of il-13 in mice resulted in impaired th2 cell development and indicated an important role for il-13 in the expulsion of gastrointestinal parasites.Il-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as il-1beta, tnf-alpha, il-6 and il-8. Il-13 has also been shown to enhance b cell proliferation and to induce isotype switching resulting in increased production of ige.Mature rhesus il-13 shares 94%, 58%, and 60% amino acid sequence identity with human, mouse, and rat il-13, respectively., Unitprot id: q864v6