Il-17a Mouse Anti-Human, Pe, Clone: Scpl1362, Bd, Mouse Monoclonal Antibody, Each

Details:

Human il-17a, also known as il-17, is a proinflammatory cytokine that is encoded by the il17a gene in chromosome 6. Il-17a is produced as a disulfide-linked homodimer comprised of two mature 136-amino acid polypeptides. It is a member of the il-17 family of structurally related cytokines, designated il-17a through il-17f. Activated memory t cells, especially th17 cells (specialized il-17a-producing cd4+ t cells distinct from th1 and th2 cells) produce il-17 and provide protective immunity against pathogens. Activated cd8+ t cells, γδt cells, nk cells and neutrophils can also be activated to produce il-17a. Il-17a binds to and exerts its biological activity through il-17 receptors (il-17r) that are expressed by a variety of target cells including fibroblasts, epithelial and endothelial cells, monocytes/macrophages and mast cells. The ubiquitous il-17r expression pattern may explain the broad tissue responsiveness to il-17. Il-17 induces stromal cells to secrete cytokines and chemokines involved in inflammatory and hematopoietic processes. For example, il-17 induces fibroblasts to produce il-6, il-8, g-csf and express increased surface icam-1. The scpl1362 antibody reacts with human il-17a.Host species: mouseclone: scpl1362isotype: igg1 κspecies reactivity: humanintracellular staining