Il-17f Mouse Anti-Human, Pe, Clone: O33-782, Bd, Mouse Monoclonal Antibody, Each

Details:

The o33-782 monoclonal antibody specifically binds to interleukin-17f (il-17f). Il-17f is a member of the il-17 family of cytokines. Il-17f is encoded by the il17f gene located in chromosome 6 (location: 6p12). Il-17f is a proinflammatory cytokine that is produced by activated t cells including differentiated cd4+ t helper 17 (th17) cells. Activated th17 cells can express disulfide-linked il-17f and il-17a homodimers as well as il-17a/il-17f heterodimers. These il-17 dimers act by binding to and signaling through il-17 receptor complexes (il-17r). Il-17r are comprised of transmembrane il-17ra and il-17-rc protein subunits that are expressed by a variety of target cells including epithelial and endothelial cells, keratinocytes, fibroblasts, and granulocytes. Il-17f can induce target cells to produce proinflammatory cytokines such as il-1β, il-6, g-csf, gm-csf, and tnf and chemokines including cxcl1/gro-α, cxcl2/gro-β, and cxcl8/il-8 that attract and activate leukocytes, eg, neutrophils. Th17 and other il-17f-producing cells play protective roles in the clearance of extracellular pathogens, including bacteria and fungi. Il-17f can also play adverse roles in inflammation associated with asthma and autoimmune diseases.Host species: mouseclone: scpl1362isotype: igg1 κspecies reactivity: huma