Il-17f Mouse Anti-Mouse, Alexa Fluor 647, Clone: O79-289, Bd, Mouse Monoclonal Antibody, Each

Details:

The o79-289 monoclonal antibody specifically binds to the inflammatory cytokine protein, interleukin-17 (il-17f). Il-17f is a member of the il-17 family of cytokines. Among il-17 family members, il-17f has the highest amino acid sequence homology to il-17a. Il-17f is produced by activated cd4+ t helper (th17) cells, cd8+ t (tc17) cells and γδ t cells. Il-17f can be secreted as homodimers or as heterodimers with il-17a. Il-17f and il-17a have overlapping functions such as inducing epithelial cells and fibroblasts to produce proinflammatory cytokines and chemokines including il-6, gm-csf, cxcl1, ccl2, and ccl7. These factors attract and activate neutrophils and other cell types that mediate protective responses against pathogenic microbes or pathologic allergic or autoimmune diseases. Il-17 gene knockout studies have shown that il-17f and il-17a have independent functions as well. Il-17f and il-17a exert their biological function by binding to and signaling through il-17 receptors comprised of the transmembrane receptor subunits, il-17ra (cd217) and il-17rc.