Il-23 Rat Anti-Mouse, Percp-Cy5.5, Clone: O78-1208, Bd, Rat Monoclonal Antibody, Each

Details:

The o78-1208 monoclonal antibody specifically binds to the mouse interleukin-23 receptor (il-23r) subunit that is encoded by the il23r gene. The il-23r subunit is a type i transmembrane glycoprotein and member of the hemopoietin receptor superfamily. The mouse il-23 receptor complex is comprised of il-23r and il-12 receptor beta 1 (il-12 rβ1) subunit s. The il-23r complex can bind il-23, a cytokine that plays roles in innate and adaptive immunity as well as in autoimmune diseases, eg, by the generation and maintenance of th17 cells. Mouse il-23r is expressed by activated/memory cd4 t cells, th1, th2 and th17 cells, γδ t cells, dendritic cells and macrophages as determined by il-23r mrna expression and il-23r-gfp reporter mouse studies. The il-23-bound il-23r complex transduces an intracellular signal pathway mediated by a jak-stat signaling cascade.