Il-4 Rabbit Anti-Mouse, Rabbit Recombinant Polyclonal Antibody, Each

Details:

This antibody is predicted to react with rat, non-human primate and rabbit based on sequence homology. Intact igg appears on a non-reducing gel as ∽150 kda band and upon reduction generating a ∽25 kda light chain band and a ∽50 kda heavy chain. Recombit rabbit polyclonal antibodies are unique offerings from thermo fisher scientific. They are comprised of a selection of multiple different recombit monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombit antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombit rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.Interleukin-4 (il-4) is a pleiotropic, immune-modulatory cytokine produced by activated t cells, and serves as a ligand for interleukin 4 receptor. Il-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to il13, which may contribute to many overlapping functions of this cytokine and il13. Stat6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of il-4. The il-4 gene, il-3, il-5, il-13, and csf2 form a cytokine gene cluster on chromosome 5q. In particular, il-4 is located in close proximity to il13 on the chromosome. Further, the il-4 gene, il13 and il5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. Il-4 delta 2 is a known splice variant of il-4.