Iqgap1 Mouse, Unlabeled, Clone: 24, Bd, Mouse Monoclonal Antibody, Each

Details:

Gtpases (ras, rho, cdc42hs, and rac) modulate various cellular functions such as cytoskeletal architecture, growth, motility, and gene expression. The activity of the gtp-binding proteins is regulated by factors that accelerate gtp-binding (gaps) and proteins that enhance the rate of gtp hydrolysis (gtpases). Iqgap1 is ras-gap related protein that contains a ww domain that binds poly-proline regions, a calponin-homology domain (chd), an iq domain of unconventional myosins, and a c-terminal gap-related domain (grd). Iqgap1 co-immunoprecipitates with cdc42 and calmodulin, and colocalizes with cdc42hs at the leading edges of the plasma membrane and at the cell-cell junctions. Iqgap1 may interact with both cadherins and catenins leading to dissociation of these proteins from sites of cell adhesion. Thus, iqgap1 may be a rac1 and cdc42 effector that negatively regulates cadherin-mediated cell junctions.