Jak1 Mouse, Unlabeled, Clone: 73, Bd, Mouse Monoclonal Antibody, Each

Details:

The jak family of receptor-associated protein kinases is directly involved in interferon (ifn) response pathways. The jak family contains at least three members: jak1, jak2, and tyk2. Each protein is approximately 130kda and contains a c-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, jak1 is rapidly tyrosine phosphorylated in response to ifn-α and ifn-γ. Jak1 is required for the phosphorylation of the transcription factor stat1 (p91), in response to ifns-α or ifn-γ. Jak1 is also necessary for the efficient phophorylation of stat2 (p113) in response to ifn-α and for the phosphorylation of tyk2 or jak2 in response to ifns-α or ifn-γ, respectively.Immunofluorescence, immunohistochemistry, immunoprecipitation, western blotting