Kcnj11 Rabbit Anti-Human, Mouse, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Peptide Of Kcnj11, Each

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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by g-proteins and is found associated with the sulfonylurea receptor sur. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (phhi), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant noninsulin-dependent diabetes mellitus type ii (niddm), transient neonatal diabetes mellitus type 3 (tndm3), and permanent neonatal diabetes mellitus (pndm). [Provided by refseq