Keap1 Rabbit Anti-Human, Mouse, Rat, Polyclonal, Rabbit Polyclonal Antibody, Each

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A suggested positive control is human lung tissue lysate. Pa5-34454 can be used with blocking peptide pep-1496. The pa5-34454 immunogen is located within the last 50 amino acids of keap1. Predicted molecular ∽ 70kd. In western blot applications, this antibody has been observed to detect a band at: 65-70kd. Predicted species reactivity based on immunogen sequence: pig: (100%).Keap1 (kelch-like ech-associated protein 1) is a stress sensing adaptor for the cullin3 (cul3)-dependent e3 ubiquitin ligase complex that negatively regulates nrf2 (nf-e2-related factor 2) and plays a role in the oxidative stress response. It targets nfe2l2/nrf2 for ubiquitination and degradation by the proteasome. Keap1 contains an amino terminal btb/poz domain and a carboxyl terminal kelch domain which are required for interaction with nrf2, and in binding cul3-e3 ubiquitin ligase. Altered expression of nrf2 is associated with chronic obstructive pulmonary disease (copd). Keap1 also targets the down regulation of nf-kappa-b activity by targeting ikkbeta degradation. Mutation of the keap1 gene is found in lung cancer.