Klrg1 Hamster Anti-Mouse, Pe-Cf594, Clone: 2f1, Bd, Hamster Monoclonal Antibody, Each

Details:

The 2f1 monoclonal antibody specifically binds to klrg1 ( k iller cell l ectin-like r eceptor mmunoreceptor t yrosine-based i nhibitory m otif); its ligand has not been identified klrg1 is expressed mainly as a homodimeric molecule consisting of two n-glycosylated subunits of approximately 30-38 kda. The level of klrg1 expression is reduced in mhc class i-deficient mice, although direct binding of klrg1 to mhc class i antigens could not be detected. Cross-linking of klrg1 by 2f1 mab reduces tcr-mediated ca mobilization and cytotoxic responses (but not ifn- γproduction) by cd8 t cells and inhibits ifn- γand tnf- α production and redirected lysis by nk cells. This antibody is conjugated to bd horizon pe-cf594, which has been developed exclusively by bd biosciences as a better alternative to pe-texas red™. Pe-cf594 excites and emits at similar wavelengths to pe-texas red™ yet exhibits improved brightness and spectral characteristics. Due to pe having maximal absorption peaks at 496nm and 564nm, pe-cf594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as pe-texas red™ (eg, 610/20-nm filter).